CHANGES OF THE WHOLE BLOOD VISCOSITY AND PLASMA VISCOSITY IN THE COURSE OF ACUTE MYOCARDIAL INFARCTION. EFFECTS OF CAPTOPRILE
Abstract
In this clinical study we examined the changes of the whole blood viscosity, plasma viscosity and fibrinogen which are sensitive parametres of the changes of the blood reology properties, in the acute myocardial infarction. We study the effect of the trombolytic therapy and we also attempted to evaluate the effect of the administration of captopril to patients after 24 hours and the changes of the whole-blood viscosity, plasma viscosity and fibrinogen. It is concluded that the haemoreological changes which depend on the trombolytic therapy are very important for the treatment of the Myocardial infarction and that the fibrinolytic stage which is caused by the administration οf r-TPA lasts more than 24 hours. Irrespective οf the treatment, a week after the Myocardial infarction we observed the increase of the whole-blood viscosity, plasma viscosity and fibrinogen. The administration of captopril seems to induce dicrease of the levels οf plasma viscosity and fibrinogen. One month after the onset of the infarction the levels of whole-blood viscosity are sιill high, despite the dicrease of the fibrinogen and plasma viscosity.References
Chien S, Dormandy J, Ernst Ε, Matrai Α: Clinical Hemorheology. Martinuw Nijhoff Publisjers. lloston 1987.
Wilheimsen L, et al: Fibrinogen as a risk factor for stroke and myocardial infarction. Ν Engl J Med, 1989; 311: 501-5.
Most AS, Ruouo ΝΑ, Gewirt Η: Effect of reduction in blood viscosity on maximal myocardioal oxygen delivery distal to a moderate coronary stenosis. Circulation 1986; 74: 1085-92.
Fuchs J, Weinberger I, Tebout Α, Rotenberg Ζ: Plasma viscosity and hematoctit in the course of acute myocardial infarction. Eur Heart J 1987; 8: 1195.
Βασιλειάδης Π. Καθορισμός φυσιολογικών τιμών ιξώδους ολικού
αίματος. Διατριβή επί δικτατορία . Αλεξανδρούπολη 1993.
Παπαϊωακείμ Μ. Διδακτορική διατριβή. Το ιξώδες του πλάσματος και του ορού ως διαγνωστικός δείκτης 1990. Αλεξανδρούπολη 1991.
Ernst E, Kranth V, Resch KL, Paulsen HF. Does blood rheology revent to normal after myocardial infarction; Br Heart J 1990; 6: 248-50.
Arnst HR, Pervhalla G, Roll D, Heits J; Blood rheology in acute myocardial infarction: effects of high-dose i.ν strcptokinase compared to placebo Eur Heart J 1992; 13: 275-80.
Braunwald, Ε, Preffer ΜΑ. Venticular enlargement and remodeling following Α.Μ.Ι: Mechanisms and Management. Am J Cardiol 1991; 68: ID-6D.
Hoffmann JJ. Blood viscosity and platelet function in trombolytic therapy of acute myocardial infarction. Eur Jeart J 1990; II Surrl F (29-35).
Harkness: Review article. The viscosity of Human Blood plasma. Biorheology 1971; 8: 171 193.
Jank, Chien S, Bigger Τ: Observation on blood viscosity after acute myocardial infarction 1975; 51: 1079-84.
Mares Μ. Bertoloc, Terrible V, Girolami Α: Hemorheological Study in
Patients with Coronary Artery Disease. Cardiology 1991; 78: 111-16.
Pindur G, Sen C, Wentel Ε, Jung F: Modern strategies for treatment of acute myocardial infarction: significance of haemostaseological anf rheological findings. Αdν Exp Med Biol 1990; 281 (389 - 94).
Nicolaides ΑΝ, Bowers R, Horbourne Τ, Kinler Ρ Η: Blood
viscosity, red cell flexibility, haematocrit and plasma fibrinogen in patients with angina. Lancet 1977, 1: 943-5.
Lowe GDO, Drymmond ΜΜ, Lonimer AR: Relation between extent of coronary artery disease and blood viscosity. Br Med J 1980; I: 613-14.
Belch JJ, McArdle ΒΜ, Burnw Ρ, Lowe GDO, Forbes CD: The effects of
acute smoking on platelet behaviour, Fibrinolysis and haemoreheology inhabitual smokes. Tromb Haemost 1984; 51: 6-8.
Rouleau JL, Μove LA, Dechamlain J, Klein Μ: Activation of Neurohymoral System following Α.Μ.Ι. Am J Cardiol 1991, 68: 80D - 85D.
Mc Alpine ΗΜ, Morton JJ, Leckie Β, Runleyt, Gillen G, Dargie HJ :
Neuroendocrine activation after acute myocardial infarction. Br Heart J 1988; 60: 117-24.
Francis GS: From Risk to Reality: Coronary artery Disease. Potential
Mechanism by which coronary ischemic events are reduced. 3th Int Sym. Ab. Geneva 1993.
Tan LB, Jalil JE, Pick R, Janicki JS, Weber ΚΤ: Cardiac myocyte necrosis induced by angiotensin ΙΙ. Circ Res 1991; 69: 1185-95.
Lindpaintner Κ, Garten D. The Cardiac renin angiotensin system: an
apraisal of present experimental and clinical evidence. Circ Res 1991; 68: 905-21.
Save. Ν Engl. J Med 1992; 327: 669-77.
