EPILEPTIC SEIZURES, AFFECTIVE AND BEHAVIOURAL DISORDERS ΙΝ PATIENTS WITH CAVUM SEPTI PELLUCIDI
Abstract
Twenty three patients with cavum septi pellucidi (C.S.P.) were found among 785 patients who had received computerized tomographic scanning in Neurologic Clinic of General Hospital of Alexandroupolis. A Clinical evaluation of these patients was made to examine incidence of epileptic attacks and affective disorders in patients with C.S.P. The results obtained were as follows: 1) Ιncidence of C.S.P. was 2,9% of the patients (23 patients among 785). Sex ratio was M:F 2,28:1,0. 2) Epileptic attacks there were in 17,39% of the patients with C.S.P. (4 patients among 23). Frequency of epileptic attacks was significantly higher as compared with the patients without C.S.P. 3) Affective disorders with aggessive behaviour there were in 13,04% of the patients with C.S.P. (3 patients among 23). 4). 2 patients among 23 were alcoolics (8,6%). 5) E.Ε.G. abnormalities no specific to C.S.P. were found in 2 among 4 patients with epileptic attacks (50%).References
Frye G.D., Mc Cown Th. J. and Breese G.R. (1983) chatacterization of susceptibillity to audiogenic seizures in ethanol - dependent rats after microinjection of y - aminobutyric acid agonist into inferior colliculus, substantia migra or medial septum. The J. of Pharmacology and Exper. Therapeutics. 227 (3): 663-670.
Akiyama K., Sato Μ., Sora I., Otsuki S. , Wake Α., Fuki Η., Takahashi Υ., Yamagida Κ. , Sudara Μ., (1983). Α study of incidence and symptoms in 71 patients with caνum septi pellucidi. No Το shinkei, 35 (6): 575-581.
F.A. Elliot (1978). The corpus callosum, cingulate gyrus, septum pellucidum, septal area and fornix. In: Handbook of Clinical Neurology. (Ρ. JVinken and G.W. Bruyn, Ed) Vol. 2 p.p. 758-775. North - Holland
Publishing Company. Amsterdam - New York Oxford.
Graig D.E., Codd T.C., Huntington Η. W. (1968) Reticulum cell sarkoma of the septum pellucidum J. Neyrosurg., 29: 183- 188.
Zuska Κ. (1969). Electroencephalogram in agenesis of septum pellucidum in man. Electroencephalogr. Clin. Neurophysiol, 26 (2): 229.
Grosman S.P. (1978). An experimental dissection of the septal syndrome. ln: Functions of the septo - Hippocampal system. Ciba Foundation Symposium 58 (new series) p.p. 227-273.
Clemente C.D. and chase Μ.Η. (1973) Neurological substrates of aggressiνe behaνior. Ann. Reν. Physiol., 35: 329-356.
Coldstein Μ. 1974. Brain research and νiolent behaνior. Arch. Neurol., 30: 1-8.
Rubenstein Ε. Η. and Delgado l.M.R. (1983) lnhibition induced by forebrain stimulation in the monkey. Amer. J. Physiol., 205: 941-948.
Ciric I., Ζivin I., (1975) Neuroepithelial (colloid) cysts of the septum pellucidum. J. Neurosurg., 43 (1): 69-73.
. Zeman W. and King F.A. (1958) Tumors of the septum pellucidum and adjacent structures with abnormal affectiνe behaνior: an anterior midline struνture syndrome. J. nerν. ment Dis 1958: 490-503.
Poeck Κ. (1978) Pathophysiology of emotional disorders associated with brain damage. ln:Handbook of Clinical Neurology. (Vinken P.J. and Bruyn G.W. ed.) Vol. 3. p.p. 343-367. North-Holland Publishing Company. Amsterdam - New York - Oxford.
Health R.E. (1962). Common chatacteristics of epilepsy and schizophrenia: clinical obserνation and depth electrode studies. Am J. Psychiatry, 118: 1013-1026.
Olney J. W., De Gubareff Τ. and Labruese J. (1983). Seizure-related brain damage induced by cholonergic agents. Nature, 301: 520-524.
Health R.E. (1962). Common characteristics of epilepsy and schizophrenia: clinical obserνation and depth electrode studies. Am J. Rsychiatry, 118: 1013-1026.
Mathew R.J., Partain C.L., Prakash R., Kylkarni Μ. V., Logan Τ.Ρ. and Wilson W.H. (1985). Α study of the septum pelluciolum and corpus callosum in shcizophrenia with MR imaging Act phsychatr. scand., 72: 414-421.
Ευαγγελία Ι. Αποστόλου (1989). Μελέτη της κυτταρικής μορφολογίας και κυτταροαρχιτεκτονικής του διαφανούς διαφράγματος του ανθρώπου.
Διδακτορική Διατριβή. Επιστημονική επετηρίδα του Τμήματος Ιατρικής της Σχολής Επιστημών Υγείας του Α.Π.Θ . Παράρτημα αριθμ. 122/444. Πανεπ. έτος 1988- 89.
Harkmark V., Mellgren S.I. and Srebro Β. (1975). Acetylcholinesterase histo-chemistry of the septal region in rat and human: distribution of enzyme actiνity. Brain Res., 95: 281 -289.
Sofroniew M.V., Eckenstein F., Thoenen Η . and Cuello A.C. (1982) Topography of scoline acetyltransferase - containing neurons in the Forebrain of the rat. Neurosaence Letters, 33: 7-12.
Lewis P.R., Shute C.C.D. and Silνer Α. (1967). Confirmation from choline acetylase analyses of the massiνe cholinergic innerνartion to the rat hippocampus. J. Physiol (Lond.)., 191: 215-224.
Ottersen Ο.Ρ. and Storm - Mathisen J. (1984) Glutamate - and GABA - containing neurons in the mouse and rat brain as demonstrated with a
new immunocytochemical technique. J. Comp. Neur., 229: 374-392.
Kohler Ch. and Chan - Palay V. (1983). Distribution of y - aminobutycic acid containing neurons and terminals in the septal area. Anat. Embryol., 167: 53-65.
Domino E.F. 1976. Cholinergic enzyme actiνity in the septum and related brain areas in deseased, mentally normal, chronic schizophrenic
and organic brain syndrome patients: ln: The septal nuclei (J.F. De France, ed) p.p. 267-282. Plenum Press - New York.
