POPULATION STUDIES ΟΝ UNCONJUGATED HYPERBILIRUBINAEMIA - GILBERT'S SYNDROME
Abstract
Total serum bilirubin concentration was measured in 209 normal fasting individuals (91 males, 118 females). Ιt was also measured in 74 individuals just after food intake and in 22 after a whole night fasting before and after food intake. Total bilirubin concentration in the males showed a bimodal distribution with an antimode at 1.3 mg/100ml. Individuals with bilirubin concentration above this value had unconjugated hyperbilirubinaemia and probable Gilbert's syndrome. Total bilirubin concentration in the females again showed a bimodal distribution with an antimode at 1.0 mg/100ml. It is conceivable that females with bilirubin levels above this also have Gilbert's syndrome. This suggests that the population incidence of Gilbert's syndrome could be as high as high as 7% and that the males: females incidence is 1:4.References
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