COPPER CONTENT IN THE BLOOD OF PREGNANT WOMEN AND THEIR NEWBORN IN NORMAL AND PATHOLOGICAL PREGNANCIES
Abstract
In 464 pregnant women we examined the Cu (copper) quantities in the blood and serum and also in the blood and cord of newborn. For comparison we studied the corresponding samples from 100 non-pregnant women who did not take contraceptives. The results from the above investigation are the following: I. The values of cu (copper) in the blood and in paricular in the serum of pregnant women are much more higher than those of non-pregnant women and from the mean value observed in litarature. II. The Cu (copper) values in the blood and serum are equal in the women who became for the first time and those with multiple pregnancies with physiological and pathological pregnancies. III. The concentrations of Cu (copper) in the blood of the cord is independent from the values of Apgar of newborn or from physiological or pathological evaluaation of pregnancy. IV. In contrast with the quantity Cu (copper) in the blood of mothers, the concentration of copper in the blood of coord of the newborn is much lower. The degree with which the copper is diminished in the male newborn is much higher than in female ones. V. In the pregnant women of subgroup 7-16 was found that the concentrations of copper in the blood are higher and in the serum very high. In the blood of the cord of the newborn in these subgroup the quantities of Cu are uniformally lower.References
Seeling, W. Seeling, I., Grunert, A.: Spurenelemente in der parenteralen Ernahrung. Klinik arzt, 1979, 8: 145-150.
Riemschneider, R., Martins, A.F.: Bestimmung von Spurenelementen in der menschlichen Plazenta. I. Mitteilung: Spektralphotometrische Bestimmung des Kupfergehaltes von Hunanplazenten. Geburtshilfe und Frauenheilkd, 1978, 38: 371-375.
Uteg, K. H. m Kurze, P., Uhlemann, E., Kreli, R.: Zur Komplexchemie der Cuproine. VII. Uber die Verwendung von 3, 3-Dimethylen, 2,2-dichinchoninsaure zur photometrischen Kypferbestimmung in biologischen Material. Dtsch. Gesundheitsw, 1971, 26:1785-1787.
Maas, D.H., Hinckers H.J.: Der Serumkupfer / Serumeisen - Quotient bei malignen Tumoren des weiblichen Genitale. Geburtshilfe Frauenheilkd, 1975, 35:619-626.
National research council: "Recommenden Dietary Allowances" 8th ed., pp 95-96. National Academie of Science, Washington, D.C. 1974.
Shearer, T.R., Lis, E.W., Johnson, K.S., Johnson, J.R., Prescott, G.H.: Copper and zinc in the amniotic fluid and serum from highrisk pregnant women. Proc. Soc. Exp. Biol. Med, 1979, 161:382-385.
Evans, G.W.: Copper Homeiostasis. in: Gladtke, E., Heimann. G., Eckert, I.: Spurenelemente - Analytic, Umsatz, Bedarf, Mangel und Toxikologie. Thieme, Stuttgart, 1979.
Seeling, W., Ahnefeld, F.W., Dick, W., Frunert, Α., Maroske, G., Mayer, R., Milewski, Ρ., Rommel, K.: The trace elements chronium, magnese, copper and zincin fetal liver tisesue. J. Perinat. Med, 1977, 5:178-189.
Menkes, J.Η., Alter, Μ . Steigleder, G.K., Weakley, D.R., Sung, J.H.: Α sex-linked recessive disorder with retardation of growth, peculiar hair and focal cerebral an cerevellar degeneration. Pediatrice, 1969, 44: 764-778.
Toaff, R., Toaff, Μ.Ε., Peyser, M.R., Streifler, Μ.: Hepatolenticular degeneration (Wilson's desease) and pregnancy. Α reνiew and report of a case. Obstet. Gynecol. Surg, 1976, 32: 497-507.
Holtmeier, H.J., Juhn, M., Rummel, K.: Zink, ein lebenswichtiges Mineral. Wissenschaftliche Verlagsgesellschaft, Stuttgart 1976.
Hurley, L.S.: Trace elements and teratogenesis. Med. Clin. North Am, 1976, 60: 771-778.
Karlson, P.: Kurzes Lehrbuch der Biochemie. 6. Aufl. Themie, Stuttgart 1967.
Alessandrini, A., Semino, G.: Sul significato clinico della cupremia in ostetricia e ginegologia. Atti Ssoc. Ostet. Gine, 1959, 8: 12-15.
Kaeser, Η.Ε.: Motorische Storungen. in : Siegenthaler W.: Klinische Pathophysiologie. Thieme, Stuttgart 1970.
Oνerzier, C.: Systematik der inneren Medizin. 3. Aufl. Thieme, Stuttgart 1970.
Hill, C.H., Matrone, G.: Chemica parameters in the study of in vivo and in vitrο interactions of transition elements. Fed. Proc. 29, (1970) 1474-1481.
Eνans, G.W.: Copper homeostasis in the mammalian system Physiol. Reν, 1973, 53 : 535-537.
Giedroyc, Β., Pankiewicz, Μ., Surma, Η.: Vergleichende Untersudnungen uber Serumeisen-und Serum - Kypferspiegel bei Frauen mit Adnexentzundrungen in Verlauf der Behand - Lung mit Hydrocortison und Moorpaste. Zbl. Gynak, 1966, 88: 1654-1658.
Kautzsch, Ε.: Eisen - und Kypferstoffwechsel bei malignen Neoplasien. med. Wschr, 1959, 40: 1851-1858.
Keiderling, W., Scharpf, Η.: Uber die Klinische Bedeutung der Serumkupfer - und Serumeisen - Bestimmung bei neioplastischen Krankheitszustanden. Munch. med. Wschr, 1953, 95: 437-442.
Rummel, Α.: Die Bewertung des Eisen - und Kupfersρίegels der gesunden und Kranken Frau. Med. Klin, 1959, 54: 1062-1069.
Thieme, R., Klose, B.J., Schrammel, Ρ., Samsahl, Κ.: Das Verhalten von essentiellen Spurenelementen in Verlauf der normalen und pathologischen Schwangerschaft. Ein Beitrag zur Diagnose der Plazentainsuffienz. Ε., Heimann. G., Eckert, I: Spurenelemente-Analytik, Umsatz, Bedarf, Mangel und Toxikologie. Thieme, Stuttgart 1979.
