STUDY OF PROLACTIN, LH, FSH LEVELS FOLLOWING EPILEPTIC SEIZURES
Abstract
Because of the controversial bibliographic data a study of prolactin, as well as gonadotropic hormones levels in epileptic patients' serum following a partial or generalized seizure is attempted in this paper. Prolactin and gonadotropic hormones levels in the serum of 14 epileptic patients (5 male, 9 female) were studied both postictally (within 2 hours after the occurance of the seiruze) and interictally using immunofluorescent methods. (Three of them had temporal seizures, 3 termoral with secondary generalization, 1 psychomotor with secondary generalization and 7 grand mal seizures). It has been found that 8 out of the patients showed increased prolactin but normal LH-FSH levels postically. Serum prolactin level is not an accurate method of diagnosing epileptic seizures. There is possibly an influence either of the particular anticonvolsive medication, or the duration of the seizure.References
Abbott RJ, Browning MCK, Daνidson DLW: Serum prolactin and cortisal concetrations after grand mal seizures. J Neural Neurosurg Psychiatry 1980, 43:163-67.
Ο'Dea J, Gould D, Hallberg Μ, Wieland R: Prolactin changes during electroconvulsive therapy. Am J Psychiatry 1978, 135:609-11.
Ohman R, Walinder J, Balldin J, et al: Prolactin response to electroconvulsive therapy. Lancet 1976, 936-37.
Trimble RM: Serum prolactin in epilepsy and hysteria. Br Med J 1978, 2:1682.
Pritchard ΒΡ, Wannamaker ΒΒ, Sagel J, Daniel MC: Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures. Ann Neurol 1985, 18:87-9.
Pritchard ΡΒ, Wannama Ker ΒΒ, Sagel J, Nair R, De Villier C: Endocrine function following complex partial seizures. Ann Neurol 1983, 14:27-32.
Gaidos L, Matias-Guiu J, Fraile Μ: Genolla J-serun prolactin in evaluation of epileptic seizures. J Neural 1987, 234:191.
Laker KD Mulloly JP, Howell Β: Prolactin changes after seizures classeified by EEG monitoring. Neurology 1985, 35:31-5.
Wyllie Ε, Luders Η, Mac Millan JP, Grupta Μ: Serum prolactin levels after epileptic seizures. Neurology 1984, 34:1601-4.
Mc Lead RM: Regulation of prolactin secretion in Frontiers in Neuroendocrinology, Vol 4. Ed. Martini L, Ganong WF. New York, Raven Press. 1975, 169-94.
Ι Noue Υ, lmazato Κ, Arikawa Κ, Miura Τ: Clinical effects of L-dopa on epilepsy. Folia psychiatr Neural Jpn. 1979, 33:307-9.
Schaan CJ, Clemens JA: The role of catecholamines in the release of anterior pituitary prolactin in vitro. Endocrinology 1974, 95:1202-12.
Schally ΑV, Redding TW, Arimura Α, Dupont Α, Lιnthicum JL: Isolation of gamma-aminobutyric acid from pig hypothalamus and demostration of its prolactin-release inhibiting (PIF) activity in vino and in vitro. Endocrinology. 1977, 100:681-91.