ANTIBODIES TO DIFFERENT VIRUS ΙΝ MATERNAL AND CORD SERA
Abstract
The aim of this study was to determine viral antibodies in maternal and cord sera of 120 consecutive deliveries. The following antibodies: Epstein - Barr virus (EBV), Cytomegalovirus (CMV), Herpes simplex virus (HSV), and Rubella (RUB) were determined by immunoabsorbent assay (Elisa). 52 infants with one or more risk indicators (weight <3Kgr, Apgar score <7, meconium-stained amniotic fluid, respiratory distress syndrome) were defined as «at risk». 68 infants free of such indicators were defined as «normal». Analysis regarding individual viruses showed significantly higher titers to CMV and RUB in cord blood, and similar levels of antibodies to EBV and HSV in maternal and cord blood. Significantly lower antibody levels to all 4 viruses were found in both maternal and cord blood of the «at risk» group, as compared to the normal group. Birth defects were found to have no effect on antibody titers. These results indicate an efficient and selective transfer through the placenta of certain viral antibodies and the possible association of lower antibody production, with the presence of risk indicators in the infants.References
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