ANTIGLIADIN (AGA), ANTIRETICULIN (R1-ARA) AND ANTIENDOMYSIAL (ΕΜΑ) ANTIBODIES ΙΝ COELIAC DISEASE
Abstract
Antibodies against reticulin (R1-ARA), gliadin (AGA) and endomysial (EMA) were determined by both IFL and ELISA for R1-ARA and AGA, and IFL for EMA, in a coeliac disease patient with positive gut biopsie. Antigliadin and antireticulin antibodies were positive at 1:40, but antiendomysial antibodies were negative. The high sensitivity and specificity of the above antibodies could permit us to use them as screening test in patients with coeliac disease and their relatives before effectuating a gut biopsie.References
lmmunologia Medica, F. Dammacco Vol 2 985-997, 1989.
Clinical lmmunology Helen Chapel Mausel Haeney 1984, 339-342.
Volta U, Lenzi Μ, Lazzari R, Cassani F, Collina Α, Bianchi F, Pisi Ε.: Andibodies to gliadin detected by immunofluorescence and micro Elisa method: markers of actνe childhood and adult coeliac disease Gut, 1985, 26, 667-671.
Οlavi Hallstrom.: Comparison of lgA class reticulin and end Ο mysium antibodies in coeliac disease and dermatitis herpetiformis Gut, 1989, 30,
-1232.
Volta U, Bonnazzi C, Ρisi Ε, Salardi. S, Cacciari Ε.: Antigliadin and antireticulin antibodies in coeliac desease and at onset diabets in children. Lancet 1987 ii:1034.
Dias J, Unworth DJ, Walker-Smith JA.: Antigliadin and antireticulin antibodies in screening for coeliac disease Lancet 1987, 157-8.
Unworth DJ, Manuel ΡD, Walker - Smith JA. Campdell CA, Johnson GD, Holborow EJ.: Α new immunofluorescence bloodtest for gluten sensitiνity. Arch Dis. Childhood 1981, 56:864-68.
Volta V, Lazzari R, Bianchi F, Lenzi Μ, Baldoni AM, Cassani F, Collina Α, Pisi Ε: Antibodies to dietary antigens in coeliac disease Scand J . Gastroent, 1986, 21 :935-940.
Lancaster - Smith, Kumar Ρ, Clark ML, Marks R, Johnson GD: Antireticulin antibodies in dermatitis herpetiformis and adult coeliac disease Br. J. Dermato 1975, 92, 37-42.
Volta U, Malinato Ν, Lenzi Μ, Cassani F, Fusconi Μ, Ballardini C, Zauli D, Bianchi F.B.: Comparison between lgA antiendomysial R1-antireticulin
and antigliadin antibody in adult coeliac disease.
Volta U and al: lgΑ antiendomysial antibody test: Α step forward in coeliac disease screening: in press 1991 Digestiνe diseases and Sciences.
Mallas EG, Williamson Ν, Cooper BT, Cooke.: lgA class reticulin antibodies in relatiνes of patients with coeliac disease Gut 1987, 18:647-50.
Auricchio S, Mazzacca G, Tosi R, Visakorpi J, Maki Μ, Polanco J.: Coeliac disease as a familial condition: ldentification of asymptomatic
coeliac patients with family groups. Gastroenterol. lnt. 1988, 1 :25-31.