LIVER HISTOLOGY ΙΝ PREGNANT AND NEONATAL RATS AFTER ΟΝΕ HALOTHANE EXPOSURE ANESTHESΙA

Authors

  • Μ. ΚΟΥΓΙΟΥΜΤΖΗΣ
  • Κ. ΣΙΜΟΠΟΥΛΟΣ
  • Ν. ΝΙΚΟΛΕΤΤΟΣ
  • Ι. ΑΝΔΡΟΥΛΑΚΗΣ
  • Ε. ΣΙΒΡΙΔΗΣ
  • Α. ΠΟΥΛΙΟΥ

Abstract

This study in neonatal rats (24 hours) concerns the influence of one exposure halothone to their mothers on liver histology, 24 hours before the delivery and one week before the delivery. We used one control group A (n= 15) and one study group Β (n=95). The animals of the study group were divided in two subgroups. The animal's mothers of the first subgroup B1 (n=50) were exrosed in halothone 24 hours before the delivery and the animal's mothers of the second subgroup B2 (n=45) were exposed in halothone one week before the delivery. The changes in liver histology on neonatal rats were quantitative and limited and there were no signals of liver necrosis.

References

Beffrage, S. et al: Halothane hepatitis in an anaesthesist. Lancet, 1966, 1466-67.

Κlatskin, G. et al: Recurrent hepatilis attributable to halothane sensitization in the anaesthetist. New England J. Med, 1969, 280:515- 518.

Johnston, C.Τ, Mendelson, F: Halothane Hepatitis in a Laboratory Techrician. Aust. Ν. Ζ. J. Med, 1971: 2, 171-173.

Scherlock, Sh: Progress report: Halothane Hepatitis. Gut, 1971, 12: 324-329.

Inman, W.H.W, Mushin, W.W: Jaudice after Exposure to Halolane: An Analysis of Reports to the Commitee on Safety of Medicines. Br. Med. J, 1974, 1:5-10.

Wright, Ε. et.al: Controlled prospectiνe study of the effect on liνer function of multiple exposures to halothane. Lancet, 1975 April 12.

Trowell, J. et al: Controlled trial of repeated halothane anesthetics in patients with carcinoma of the uterine cerνix heated with radium. Lancet, 1975, 1: 821.

Walton, Β. et al: Unexplained hepatitis following halothane. Brit. Med. J, 1976, 1171-1176.

Boersch, G, Schimdt, G: Halothane-assoxiierte leberschaeden: Metabolische, immunologische und genetische Mechamismen. Med. Klin, 1987, 450-455 (Nr. 12/13).

Brohult, S: Liνe reaction after halothane and diethyl ether anaesthesia. Acta anaesth. Scandinaνica, 1967, 11: 201-220.

Schlebusch, Η. et al: Der Einfluss der Narkose auf day postoperatiνe νerhalten von Lebenzymen und Eiweissfraktionen. Fortschr, Med. 1977, 95 (10): 662-8.

Tompson, D.S. et al: Changer in Liνer Enzyme Values after Halothane and Enflurane for Surgical Anesthesia. Southern Medical Journal, 1978, 71, 7: 779-782.

Koenig, Α. et al: Day dederenzymmuster nach "atraumatiscen" operatiνen Eingriffen under Halothan -und Neurolept- anaesthesie. Prakt. Anaesth., 1979, 14, 5: 430-6.

Garstka, G. et al: Das postoperatiνe Veerhalten von Leberenzymen und Bilirubin nach νerschiedenen Narkaseνerfahren. Prakt. Anaesth. 1979, 14, 5: 412-29.

Mc Ukritm P.D.A. et al: Methodology of a prospectiνe study of changes in liνer enzyme concentrations following repeat anaesthetics. Brit. J. of Anaesthesia, 1979, 51: 1125-32.

Durdee, J.W: Problems of multiple inhalation anaesthetics Br. J. Anaesth, 1981, 53 Suppl. 1: 63-67.

Sear, J.W. et al: Hepatic Function after anaesthesia for major νascular reconstructiνe surgery. Br. J. Anaesth, 1983, 603-609.

Hughes, H.C, Lang C.M: Hepatic necrosis produced by repeated administration of halothane to quinea pigs. Anaesth. 1972, 36: 466-471.

Mc Lain, G.E. et al: An animal model of halothane hepatotocicity: Roles of enzyme induction and hypoxia. Anaesthesiology, 1979, 51: 321-326.

Salhab, A.S. et al: Hepatocyte reasponses to νolatile anaesthetics: Changes in surface scanning and enzyme leakage. Anesth. Analg, 1978, 57: 605-609.

Steνens, W.C. et al: Comparatiνe toxicities of halothane, in of lurane nad diethyl-ether at subanesthetic concentrations in laboratory animals. Anesthesiology 1975, 42: 408-419.

Αλβανού, Α.Ε. και συν.: Αλλοιώσεις της λεπτής υφής του ήπατος μετά από μακροχρόνια έκθεση στο πτητικό αναισθητικό αλοθάνιο. Ελλην. Αναισθ. 1981, 15, 1-2:624-28.

Chang, L.W. et al: Ultrastructural eνidence of the hepatotoxic effect of halothane in rats following in-utero exposure. Canad. Anaesth. Soc. J, 1975, 22, 3: 330-338.

Maryniak, R. et al: Ultrastructural changes in the Liνer of Newborn Rabbit after Halothane Anaesthesia. ΡΑΤ. POL. ΧΧΙΧ, 1978, 3: 313-319