YΕS OR ΝΟ ΤΟ CHEMOTHERAPY ΙΝ NASOPHARYNGEAL CANCER?
Abstract
Opinions regarding the management of nasopharyngeal cancer differ and vary conciderably. As far as treatment of choise is concernd radical radiation therapy remains the foremost modality. Chemotherapy in any form such as adjuvant, neoadjuvant, radiosensitizing and aggressive did not managge to win a definite place in the management of the nasopharyngeal carcinoma. Therapeutic response remains roor, treatment toxicity high, and oνerall surνival low. The developement of a possible therapeutic combination including radiosensitizing low dose chemotherapy, differentiating agents and radiation therapy may prove beneficial.References
RUBIN Ρ.: Clinical Oncology, 7th ed. 1993; 345-348
HOLLAND J., FREI Ε., BAST R., et al: Cancer Medicine, 3rd ed. 1993; 1242-1244
DeVITA V., HELLMAN S., ROSENBERG S.: Cancer-Principles & Practice οf Oncology, 4th ed. 1993; 597-604
CVITKOVIC E., DROZ J.P., ARMAND J.P., et al: Handbook of Chemotherapy in Clinical Oncology, 2nd ed. 1993: 643-648
ΜΑNOLAKIS G.: Lectures in Clinical Oncology, Univ. Press. MEDUNSA. 1993: 38-40
MULKERIN L.: Practical Points in Radiation Oncology. Med. Εxam. Ρubl., 1979: 45-48
ΑΔΑΜΟΠΟΥΛΟΣ Γ.: ΟΓΚΟΛΟΓΙΑ Παπαβασιλείου, Κουβάρη, κ.α.: Καρκίνος του Ρινοφάρυγγα. 1991; 456-462
CASCIATO D.A., LOWITZ Β.Β.: Μanual of Bedside Oncology, Little Βrown Co. 1984; 134-135
SKEEL R.: Μanual of Cancer Chemotherapy, Little Brown Co., 1984; 71-82
ΔΗΜΟΠΟΥΛΟΣ Ι.: Πρόοδοι στη Διάγνωση και Θεραπεία του Καρκίνου του Ρινοφάρυγγα, 4ο Διαπανεπιστημιακό Ακτινολογικό Συνέδριο, Θεσσαλονίκη, 17-20 Νοέμβρη, 1994
Al-SARRAF Μ., PAJAK Τ., MARCIAL /., et al: Concurrent Radiotherapy and Chemotherapy with Cisplatin in Inoperable Squamous Carcinoma of the Head and Neck: An RTOG Study, Cancer 1987; 59: 259-265
