ΤΗΕ PROGNOSTIC SIGNIFICANCE OF ARGYROPHILIA ΙΝ ENDOMETRIAL ADENOCARCINOMAS
Abstract
Α series of 74 endometrial adenocarcinomas was investigated for the presence οf argyrophilia by the Grimelius technique. Argyrophil cells were detected in 39 cases (52.7%). Adenocarcinomas of the endometrium containing argyrophil cells had clinical and pathological features similar to ordinary endometrial adenocarcinomas. However, prognosis, in terms of 5-year survival, was appreciably higher in patients whose neoplasms contained argyrophil cells compared to those whose neoplasms were devoid of such cells. These findings indicate that endometrial neoplasms with argyrophil cells are not a separate clinical or pathological entity, but their distinction from other forms οf endometrial adenocarcinoma is useful because of a different biological behaviour.References
Ueda G, Yamasaki Μ, Inoue Μ, Kurachi Κ: Α clinicopathological study of endometrial carcinomas with argyrorphil cells. Gynec Oncol 1979; 7:223-232.
Bannatyne Ρ, Russell Ρ, Wills Ej: Argyrophilia and endometrial carcinoma. Int J Gynec Pathol 1983; 2:235-254.
Sίvridis Ε, Buckley CH, Fox Η: Argyrophil cells in norrnal, hyperplastic, and neoplastic endometrium. J Clin Pathol 1984; 37:378-381.
Aguirre Ρ, Scully RE, Wolfe HJ, Delellis RA: Endometrial carcinoma with argyrophil cells: a histochernical and immunohistochemical analysis. Human Pathol 1984; 15:210-217.
Kurman RJ, Norris HJ: Endometrial neoplasia: hyperplasia and carcinoma. In: Blaustein Α, ed. Pathology of the Female Genital Tract. Second Edition. New York: Springer - Verlag, 1982:311-351.
Sivridis Ε.: An immunohistochemical study of endometrial hyperplasia and neoplasia. Ph. D. Thesis, 1986: University of Manchester.
Hendrickson MR, Kempson RL. Surgical Pathology of the Uterine Corpus. Philadelphia: WB Saunders, 1980.
Grimelius L.: Α silver nitrate stain for a2 cells in human pancreatic islets. Acta Soc Med Upsal 1968; 73:243-270.
Κaplan ΕL, Meir Ρ.: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481.
Ueda G., Nishino Τ., Saito J., et al.: Detection of chromogranin in argyrophil cells of endometrial carcinoma. Gynec Oncol 1987; 27:159-165.
lnoue Μ, Ueda G., Yamasaki Μ., et al.: Capacity for amine-precursor uptake and decarboxylation of argyrophil cell adenocarcinoma of the endometrlum. Gynec Oncol 1982; 13:19-25.
Inoue Μ., Ueda G., Yamasald Μ, et al: Endometrlal argyrophil cell adenocarcinoma with indole - or catecholamin precursor uptake and decarboxylation. Int J Gynec Pathol 1982; 1:47-58.
lnoue Μ, Ueda G, Yamasaki Μ, et al.: An in νitro incubation study of amineprecursor uptake and decarboxylation in the cytoplasm of argyrophil cell adenocarcinoma of the endometrium. Gynec Oncol 1982; 14: 75-79.
Pearse AGE: The APUD cell concept and its implications in pathology. Pathol Annu 1974; 9:27-41.
Pearse AGE, Polak JM: Endocrine tumours of neutral crest origin: neurolophomas, apudomas and the APUD concept. Medical Βίοl 1974; 52:3-18.
