CLINICAL EVALUATION OF ΤΗΕ EFFECTIVENESS OF ΤΗΕ COMBINATION OF IPRATROPIUM AND SALBUTAMOL ΙΝ ΤΗΕ TREATMENT OF ASTHMA AND COPD

Authors

  • Γ. ΠΑΤΛΑΚΑΣ
  • Κ. ΥΨΗΛΑΝΤΗΣ
  • Μ. ΠΟΛΙΤΟΥ
  • Ε. ΙΩΑΝΝΙΔΟΥ

Abstract

The intent of this study is the eνaluation of the effectiνeness of one anticholinergic in combination with one beta2 adrenergic agent, per breath, whith metered dose aerosol in the treatment of asthma and COPD.

References

Berger R, Smith D. Effect of inhaled metaproterenol on exercise performance in patients with stable ' fixed ' airway obstruction. Am Reν . Respir Dis 1988;138:626-9

Braun SR, McKenzie WN, Copeland C, Κnight L, Ellersieck Μ.Α comparison of the effect of ipratropium and salbutamol in the treatment of chronic airways disease. Arch Intern Med 1989;149:544-7

Combiνent Inhalation Aerosol Study Group. In chronic obstructiνe pulmonary disease, a combination of ipratropium and albuterol is more effectiνe than either agent alone. An 85 day multicenter trial. Chest 1994;105:1411-19

Corris ΡΑ, Neνille Ε, Nariman S, Gibson GJ. Dose-response study of inhaled salbutamol powder in chronic airflow obstruction. Thorax 1983;39:292-6

Easton ΡΑ, Jaduc C, Dhinngra S, Anthonisen NR. Α comparison of bronchodilating effects of a beta2 adrenergic agent and an anticholinergic agent giνen by aerosol alone or in sequence. Ν Engl J Med 1986;315:735-739

Guidelines for management of asthma in adults: chronic persistent asthma. British Thoracic Society. Brit Med J 1990;301:651-653

Guyatt GH, Townsend Μ, Nogradi S, Pugsley SO, Keller JL, Newhouse MT. Acute response to bronchodilator. An imperfect guide for bronchodilator therapy ίn chronic airflow limitation. Arch Intern Med 1988;148:1949-52

Higgins RM, Strabling JR, Lane DJ. Should ipratropium bromide be added to beta-agonist ίn treatment of acute seνere asthma! Chest 1988;94:718-722

Karpel JP. Bronchodilator responses to anticholinergic and beta adrenergic agents In acute and stable COPD. Chest 1991;99:871- 876

Nc Giνen DV, Fentem PH, Mac Falane JT, Daνies D. Responces to the sequential Administration of salbutamol and ipratropium bromide during recoνery from Acute seνere asthma. Thorax 1984;39:227-228.

Rebuck AS, Chapman ΚR, Abbount R, et al. Nebulized anticholinergic and sympothomimetic treatment of asthma and chronic obstructiνe airways disease in the emergency room. Am J Med 1987;82:59-64

Rebuck AS, Gcnt Μ, Chapman KR. Anticholinergic and sympathomimetic compination therapy of asthma. J Allergy Clin Immυnol 1983;71:317-323

Standards for the diagnosis and care of patients with COPD (ATS Statement) Am J Respir Crit Care Med 1995;162(suppl):599

Summers QA, Taνala RA. Nebulized ipratropium ίn the treatment of acute asthma Chest 1990;97:421-429

The compiνent inhalation aerosol study. Comparison of ipratropium and albuterol is more effectiνe than either agent alone. Chest 1994;105:1411-9

Van der Palen J, ΚJein JJ, Kerckhoff AHM, Van Herwaarden CLA. Eνaluation of The effectiνeness of four different inhalers ίn patients with chronic obstructiνe Pulmonary disease. Thorax 1995;50:1183-7

Υψηλάντης Κ. Πνευμονολογία. Uniνersity Studio Press, Θεσσαλονίκη 1999.